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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.

ABSTRACT: Centrosomes have critical roles in microtubule organization, ciliogenesis, and cell signaling.¹^,²^,³^,⁴^,⁵^,⁶^,⁷^,⁸ Centrosomal alterations also contribute to diseases, including microcephaly, cancer, and ciliopathies.⁹^,¹⁰^,¹¹^,¹²^,¹³ To date, over 150 centrosomal proteins have been identified, including several kinases and phosphatases that control centrosome biogenesis, function, and maintenance.²^,³^,⁴^,⁵^,¹⁴^,¹⁵^,

SUBMITTER: Ganga AK

PROVIDER: S-EPMC11496028 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature

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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.

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