Vitamin D levels and risk of ocular disorders: insights from bidirectional and multivariable Mendelian randomization analysis.

ABSTRACT:

Purpose

This study aimed to assess the causal relationships between vitamin D levels and ocular disorders.

Methods

Independent genetic variables were obtained from genome-wide association studies (GWAS) and publicly available databases. The summary statistics for 25-hydroxyvitamin D (25(OH)D) were obtained from two large-scale GWAS studies, with sample sizes of 324,105 and 417,580 European individuals. The genetic variants of myopia, primary open angle glaucoma (POAG), anterior iridocyclitis, senile cataract, diabetic retinopathy (DR), retinal vein occlusion (RVO), wet age-related macular degeneration (WAMD) and optic neuritis were extracted from the latest release of FinnGen consortium, which contains genome data from Finnish participants. Subsequently, Mendelian randomizat

SUBMITTER: Fan S 

PROVIDER: S-EPMC11496056 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature