Metabolomic analysis reveals potential role of immunometabolism dysregulation in recurrent pregnancy loss.

ABSTRACT:

Background

Recurrent pregnancy loss (RPL) affects women's reproductive health seriously, with immune dysfunction playing a key role in its cause, yet the exact mechanisms remain elusive. We aim to investigate potential mechanisms and identify biomarkers linked to RPL.

Methods

Immune cytokine testing and metabolomic profiling were conducted on the serum of 34 RPL patients and 30 healthy individuals. The metabolic pathways of the differential metabolites were analyzed, and specific metabolites were validated through targeted profiling. Potential biomarkers were identified, and the relationships between immune cytokines and differential metabolites were explored.

Results

In the RPL group, serum interleukin-6 and interleukin-10 levels were significantly higher, while inte

SUBMITTER: Ye X 

PROVIDER: S-EPMC11496058 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature