Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.

ABSTRACT: The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)^1,2. Previous studies have expanded the catalogue of BCF genetic associations through candidate gene studies^3-7, large-scale genome-wide association studies (GWAS) of fasting BCF^8,9 or functional islet studies on T2D risk variants^10-14. Nonetheless, GWAS focused on BCF traits derived from oral glucose tolerance test (OGTT) data have been limited in sample size^15,16 and have often overlooked the potential for related traits to capture distinct genetic features of insulin-producing β-cells^17,18. We reasoned that investigating the genetic basis of multiple BCF estimates could provide a broader understanding of β-cell physiol

SUBMITTER: Madsen AL 

PROVIDER: S-EPMC11496110 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature