Application of a risk score model based on glycosylation-related genes in the prognosis and treatment of patients with low-grade glioma.

ABSTRACT:

Introduction

Low-grade gliomas (LGG) represent a heterogeneous and complex group of brain tumors. Despite significant progress in understanding and managing these tumors, there are still many challenges that need to be addressed. Glycosylation, a common post-translational modification of proteins, plays a significant role in tumor transformation. Numerous studies have demonstrated a close relationship between glycosylation modifications and tumor progression. However, the biological function of glycosylation-related genes in LGG remains largely unexplored. Their potential roles within the LGG microenvironment are also not well understood.

Methods

We collected RNA-seq data and scRNA-seq data from patients with LGG from TCGA and GEO databases. The glycosylation pathway activit

SUBMITTER: Zou B 

PROVIDER: S-EPMC11496118 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature