Formulation development, characterization, and evaluation of sorafenib-loaded PLGA-chitosan nanoparticles.

ABSTRACT: The basic purpose of this work was to develop environmentally friendly, biodegradable, and biocompatible polymeric nanoparticles of sorafenib that can effectively release the desired drug in a customized and controlled manner for targeting hepatocellular carcinoma. The solvent evaporation technique was employed for the synthesis of sorafenib-loaded PLGA-chitosan nanoparticles, followed by various experimental specifications and compatibility studies using poloxamer 407 as the stabilizer. The best nanoparticles thus synthesized were selected to be used for cytotoxicity investigations through in vitro and in vivo assessments. For the in vitro drug release tests, the dialysis bag diffusion technique was used. For both chitosan nanoparticles and PLGA loaded with sorafenib,

SUBMITTER: Mateen A 

PROVIDER: S-EPMC11496126 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature