Identification of key proteins in early-onset Alzheimer's disease based on WGCNA.

ABSTRACT:

Introduction

Early-onset Alzheimer's disease (EOAD) is sporadic, highly heterogeneous, and its underlying pathogenic mechanisms remain largely elusive. Proteomics research aims to uncover the biological processes and key proteins involved in disease progression. However, no proteomic studies to date have specifically focused on EOAD brain tissue.

Method

We integrated proteomic data from brain tissues of two Alzheimer's disease (AD) cohorts and constructed a protein co-expression network using weighted gene co-expression network analysis (WGCNA). We identified modules associated with EOAD, conducted functional enrichment analysis to understand the biological processes involved in EOAD, and pinpointed potential key proteins within the core modules most closely linked to AD pat

SUBMITTER: Li D 

PROVIDER: S-EPMC11496171 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature