Characteristics associated with progression to probable dementia with Lewy bodies in a cohort with very late-onset psychosis.

ABSTRACT:

Background

Very late-onset psychosis (VLOP) is associated with higher rates of dementia but the proportion who develop dementia with Lewy bodies (DLB) is unknown. We aimed to identify individuals with VLOP who develop dementia and DLB and characterize the risk factors for progression.

Methods

Anonymized data were retrieved from electronic records for individuals with VLOP. Patients developing dementia after psychosis were identified, in addition to those with >2 core features of DLB at the time of dementia or DLB identified by a natural language processing application (NLP-DLB). Demographic factors, Health of the National Outcome Scale (HoNOS) and symptoms at index psychosis were explored as predictors of progression to dementia.

Results

In 1425 patients with V

SUBMITTER: Gibson LL 

PROVIDER: S-EPMC11496220 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature