Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls.

ABSTRACT:

Background

While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) and bipolar (BD) spectrum disorders. There is however, limited knowledge about the longitudinal course of this relationship.

Methods

Systemic inflammation (C-Reactive Protein, CRP) and cognition (nine cognitive domains) was measured from baseline to 1 year follow-up in first treatment SZ and BD (n = 221), and healthy controls (HC, n = 220). Linear mixed models were used to evaluate longitudinal changes separately in CRP and cognitive domains specific to diagnostic status (SZ, BD, HC). Hierarchical clustering was applied on the entire sample to investigate th

SUBMITTER: Sæther LS 

PROVIDER: S-EPMC11496234 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature