Periodontal ligament stem cell tissue engineering scaffolds can guide and promote canine periodontal tissue regeneration.

ABSTRACT:

Background

The immunogenicity of allogeneic mesenchymal stem cells (MSCs) is significantly enhanced after transplantation or differentiation, and these cells can be recognized and cleared by recipient immune cells. Graft rejection has become a major obstacle to improving the therapeutic effect of allogeneic MSCs or, after their differentiation, transplantation in the treatment of diabetes and other diseases. Solving this problem is helpful for prolonging the time that cells play a role in the recipient body and for significantly improving the clinical therapeutic effect.

Methods

In this study, canine adipose-derived mesenchymal stem cells (ADSCs) were used as seed cells, and gene editing technology was used to knock out the B2M gene in these cells and cooperate with the over

SUBMITTER: Dai P 

PROVIDER: S-EPMC11496256 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature