Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas.

ABSTRACT: Conservation genomics can greatly improve conservation outcomes of threatened populations, including those impacted by disease. Understanding diversity within immune gene families, including the major histocompatibility complex (MHC) and toll-like receptors (TLR), is important due to the role they play in disease resilience and susceptibility. With recent advancements in sequencing technologies and bioinformatic tools, the cost of generating high-quality sequence data has significantly decreased and made it possible to investigate diversity across entire gene families in large numbers of individuals compared to investigating only a few genes or a few populations previously. Here, we use the koala as a case study for investigating functional diversity across populations. We utilised previou

SUBMITTER: Silver LW 

PROVIDER: S-EPMC11496358 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature