Elevated plasma protein carbonylation increases the risk of ischemic cerebrovascular events in patients with atrial fibrillation: association with a prothrombotic state.

ABSTRACT:

Introduction

Plasma protein carbonylation that reflects oxidative stress has been demonstrated to be associated with the prothrombotic fibrin clot phenotype. However, the role of protein carbonyls (PC) in predicting ischemic stroke in atrial fibrillation (AF) is largely unknown. This study aimed to investigate whether PC increase the risk of stroke in anticoagulated AF patients during follow-up.

Methods

In 243 AF patients on anticoagulation (median age 69 years; median CHA₂DS₂-VASc of 4), we measured plasma PC using the assay by Becatti, along with plasma clot permeability (K_s), clot lysis time (CLT), thrombin generation, and fibrinolytic proteins, including plasminogen activator inhibitor type 1 (PAI-1) and thrombin activatable fibrinolysis

SUBMITTER: Nowak K 

PROVIDER: S-EPMC11496363 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature