Functional bias of contractile control in mouse resistance arteries.

ABSTRACT: Constrictor agonists set arterial tone through two coupling processes, one tied to (electromechanical), the other independent (pharmacomechanical) of, membrane potential (V_M). This dual arrangement raises an intriguing question: is the contribution of each mechanism (1) fixed and proportionate, or (2) variable and functionally biased. Examination began in mouse mesenteric arteries with a vasomotor assessment to a classic G_q/11 (phenylephrine) or G_q/11/G_12/13 (U46619) agonist, in the absence and presence of nifedipine, to separate among the two coupling mechanisms. Each constrictor elicited a concentration response curve that was attenuated and rightward shifted by nifedipine, findings consistent with functional bias. Electromechanical coupling pr

SUBMITTER: Haghbin N 

PROVIDER: S-EPMC11496727 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature