Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis.

ABSTRACT: Interleukin (IL)-35 is an anti-inflammatory cytokine that regulates autoimmune diseases, including systemic lupus erythematosus (SLE). However, the association between the cytokine and disease may vary by geographical region. This study performed a meta-analysis to quantitatively assess the correlation between the serum IL-35 levels in SLE patients and sub-group analyses were conducted. Four main electronic databases-Scopus, Embase, Science Direct, PubMed-were searched for relevant studies. After a database search, Endnote software was used to find and remove duplicate studies. Random-effects models were used to estimate standard mean differences in serum/plasma IL-35 levels by Hedges' g with 95% confidence intervals (CIs). Publication bias was assessed with funnel plots, and risk of bias

SUBMITTER: Leerach N 

PROVIDER: S-EPMC11496805 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature