Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study.

ABSTRACT: Walking pace is a simple and functional form of exercise and a strong predictor of health, but little is known about its causal association with rheumatoid arthritis. This study aimed to investigate the causal effect of WP on the developing RA using Mendelian randomization analysis. The genetic variation associated with WP was selected as an instrumental variable from the latest genome-wide association studies. Summary-level data for the outcomes were obtained from the corresponding GWAS. The inverse-variance weighted method was used as the primary MR analysis. The results were further tested using a multivariable MR approach based on Bayesian model averaging. Confounders (BMI, SMK, HBP, TD) with close associations with RA were included in the analysis. An observational study with individu

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11496810 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature