Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles.

ABSTRACT: Defining spatial synchronisation of pathological beta oscillations is important, given that many theories linking them to parkinsonian symptoms propose a reduction in the dimensionality of the coding space within and/or across cortico-basal ganglia structures. Such spatial synchronisation could arise from a single process, with widespread entrainment of neurons to the same oscillation. Alternatively, the partially segregated structure of cortico-basal ganglia loops could provide a substrate for multiple ensembles that are independently synchronized at beta frequencies. Addressing this question requires an analytical approach that identifies groups of signals with a statistical tendency for beta synchronisation, which is unachievable using standard pairwise measures. Here, we utilized such

SUBMITTER: Grennan I 

PROVIDER: S-EPMC11496931 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature