Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy.

ABSTRACT:

Introduction

Effective infiltration of chimeric antigen receptor T (CAR-T) cells into solid tumors is critical for achieving a robust antitumor response and improving therapeutic outcomes. While CAR-T cell therapies have succeeded in hematologic malignancies, their efficacy in solid tumors remains limited due to poor tumor penetration and an immunosuppressive tumor microenvironment. This study aimed to evaluate the potential of low-dose radiotherapy (LDRT) administered before T-cell therapy to enhance the antitumor effect by promoting CAR-T cell infiltration. We hypothesized that combining LDRT with T-cell therapy would improve tumor control and survival compared to either treatment alone.

Methods

We investigated this hypothesis using two NSG mouse models bearing GSU or CAPA

SUBMITTER: Puebla-Osorio N 

PROVIDER: S-EPMC11496962 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature