Distinct Immune Homeostasis Remodeling Patterns after HLA-Matched and Haploidentical Transplantation.

ABSTRACT: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a widely used treatment for a variety of hematopoietic disorders, and also provides a valuable platform for investigating the development of donor-derived immune cells in recipients post-HSCT. The immune system remodels from the donor to the recipient during allo-HSCT. However, little is known about the cell profile alterations as donor homeostasis rebalances to recipient homeostasis following HSCT. Here, multi-omics technology is applied at both the single cell and bulk sample levels, as well as spectrum flow cytometry and fluorescent transgenic mouse models, to dissect the dynamics of the rebalanced homeostatic immune system in recipients after allo-HSCT. The data reveal that all immune subpopulations observed in donors ar

SUBMITTER: Guo H 

PROVIDER: S-EPMC11497014 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature