Berberine Protects against Hepatocellular Carcinoma Progression by Regulating Intrahepatic T Cell Heterogeneity.

ABSTRACT: Accumulating evidence suggests that berberine (BBR) exhibits anti-cancer effects in hepatocellular carcinoma (HCC). However, the mechanisms by which BBR regulates the immunological microenvironment in HCC has not been fully elucidated. In this study, a mouse model of orthotopic HCC is established and treated with varying doses of BBR. BBR showed effectiveness in reducing tumor burden in mice with HCC. Cytometry by time-of-flight depicted the alterations in the tumor immune landscape following BBR treatment, revealing the enhancement in the T lymphocytes effector function. In particular, BBR decreased the proportion of TCRb^hiPD-1^hiCD69⁺CD27⁺ effector CD8⁺ T lymphocytes and increased the proportion of Ly6C^hiTCRb⁺CD6

SUBMITTER: Hu J 

PROVIDER: S-EPMC11497054 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature