Thioamide-based fluorescent sensors for dipeptidyl peptidase 4.

ABSTRACT: Dipeptidyl peptidase 4 (DPP-4) is a promising biomarker for cancer and metabolic diseases. We demonstrate the design of novel fluorescent DPP-4 probes based on the protease's native substrates using a thioamide as a quencher for measuring in vitro kinetics, inhibition with sitagliptin, and DPP-4 activity in saliva samples.

SUBMITTER: Phan HAT 

PROVIDER: S-EPMC11497070 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature