Optimization and validation of multi-echo, multi-contrast SAGE acquisition in fMRI.

ABSTRACT: The purpose of this study was to optimize and validate a multi-contrast, multi-echo fMRI method using a combined spin- and gradient-echo (SAGE) acquisition. It was hypothesized that SAGE-based blood oxygen level-dependent (BOLD) functional MRI (fMRI) will improve sensitivity and spatial specificity while reducing signal dropout. SAGE-fMRI data were acquired with five echoes (2 gradient-echoes, 2 asymmetric spin-echoes, and 1 spin-echo) across 12 protocols with varying acceleration factors, and temporal SNR (tSNR) was assessed. The optimized protocol was then implemented in working memory and vision tasks in 15 healthy subjects. Task-based analysis was performed using individual echoes, quantitative dynamic relaxation times T₂ ^* and T₂, and echo time-depende

SUBMITTER: Keeling EG 

PROVIDER: S-EPMC11497078 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature