The ubiquitous P(o-tol)₃ ligand promotes formation of catalytically-active higher order palladacyclic clusters.

ABSTRACT: The Herrmann-Beller catalyst, Pd[(C^P)(μ₂-OAc)]₂, is readily formed by reaction of the cyclic trimer of 'Pd(OAc)₂' with P(o-tol)₃. In the presence of hydroxide, Pd(C^P)(μ₂-OAc)]₂ converts to [Pd(C^P)(μ ₂ -OH)]₂. Here, we report how this activated Pd precatalyst species, and related species, serve as a conduit for formation of higher order Pd _n clusters containing multiple cyclopalladated P(o-tol)₃ ligands. The catalytic competency of a Pd₄-palladacyclic cluster is demonstrated in an arylated Heck cross-coupling, which is comparable to the base-activated form of Herrmann's catalyst, namely [Pd(C^P)(μ₂-OH)]₂. The findin

SUBMITTER: Husbands DR 

PROVIDER: S-EPMC11497114 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature