Non-Alzheimer's amnestic mild cognitive impairment with medial temporal hypometabolism.

ABSTRACT:

Introduction

The increasing use of Alzheimer's disease (AD) biomarkers has led to the recognition of a subgroup of non-AD amnestic mild cognitive impairment (aMCI) patients who have medial temporal hypometabolism on fluorodeoxyglucose-positron emission tomography (FDG-PET).

Methods

In this academic memory-clinic-based consecutive series, 16 non-AD aMCI patients and 28 AD controls matched for sex, age, and baseline Mini-Mental State Examination (MMSE) were followed for a median duration of 4.5 years. Our primary outcome was the MMSE decline rate over the subsequent years. We also determined the final diagnosis over time.

Results

FDG-PET showed more pronounced medial temporal hypometabolism in non-AD cases and more inferior parietal lobule hypometabolism in AD controls.

SUBMITTER: De Keersmaecker S 

PROVIDER: S-EPMC11497174 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature