ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes.

ABSTRACT:

Introduction

Associations between amyloid-tau-neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D).

Methods

Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D (GluCog) study (N = 114), we evaluated associations between phosphorylated tau (pTau)181, pTau217, β-amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and self-administered digital cognitive tests, adjusting for age, sex, education, comorbidities (e.g., kidney disease), and glycemic indices.

Results

Higher concentrations of pTau181 and GFAP were associated with slower responses on working memory tasks (pTau181: β = 0.261; p

SUBMITTER: Fonseca LM 

PROVIDER: S-EPMC11497176 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature