An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence.

ABSTRACT: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of senescent cells is one of the hallmarks of cancer, surprisingly little progress has been made in development of strategies for their detection in vivo. To address a lack of detection tools, we developed a biocompatible, injectable organic nanoprobe (NanoJagg), which is selectively taken up by senescent cells and accumulates in the lysosomes. The NanoJagg probe is obtained by self-assembly of indocyanine green (ICG) dimers using a scalable manufacturi

SUBMITTER: Baker AG 

PROVIDER: S-EPMC11497227 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature