Detection and alterations of acetylcarnitine (AC) in human liver by ¹ H MRS at 3T after supplementation with l-carnitine.

ABSTRACT:

Purpose

Acetylcarnitine can be assessed in vivo using proton MRS (¹ H-MRS) with long TEs and this has been previously applied successfully in muscle. The aim of this study was to evaluate a ¹ H-MRS technique for liver acetylcarnitine quantification in healthy humans before and after l-carnitine supplementation.

Method

Baseline acetylcarnitine levels were quantified using a STEAM sequence with prolonged TE in 15 healthy adults. Using STEAM with four different TEs was evaluated in phantoms. To assess reproducibility of the measurements, five of the participants had repeated ¹ H-MRS without receiving l-carnitine supplementation. To determine if liver acetylcarnitine could be changed after l-carnitine supplementation, acetylcarnitine was quantifi

SUBMITTER: Savic D 

PROVIDER: S-EPMC11497247 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature