Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.

ABSTRACT:

Background

Chemokines are important mediators in immune cell recruitment, contributing to allergy development. However, extensive studies of chemokines in the circulation in relation to the presence and development of allergic diseases remain scarce. Our aim was to investigate associations of circulating allergy-related chemokines with the development of asthma and sensitization cross-sectionally and longitudinally in a population-based cohort.

Methods

The chemokines CCL17, CCL22, CXCL10, CXCL11 and CCL18 were measured in plasma samples from children in the Manchester Asthma and Allergy Study. Samples were available from cord blood at birth (n = 376), age 1 (n = 195) and age 8 (n = 334). Cross-sectional and longitudinal association analyses were performed in relation to asth

SUBMITTER: Huoman J 

PROVIDER: S-EPMC11497305 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature