Proton pump inhibitors and risk of all-cause and cause-specific mortality: A cohort study.

ABSTRACT:

Aim

To investigate the association between proton pump inhibitors (PPIs) and both all-cause and cause-specific mortality.

Methods

We conducted a cohort study using the UK Clinical Practice Research Datalink GOLD database. We compared 733 885 new users of PPIs to 124 410 new users of H2 receptor antagonists (H2Ras). In a secondary analysis we compared 689 602 PPI new users to 1 361 245 nonusers of acid suppression therapy matched on age, sex and calendar year. Hazard ratios for all-cause and cause-specific mortality were estimated using propensity score (PS) weighted Cox models.

Results

PPI prescription was associated with increased risk of all-cause mortality, with hazard ratios decreasing considerably by increasing adjustment (unadjusted hazard ratio [HR] 1.65, 95% c

SUBMITTER: Brown JP 

PROVIDER: S-EPMC11497312 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature