Research autopsy programmes in oncology: shared experience from 14 centres across the world.

ABSTRACT: While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field through synchronous, extensive, and high-volume sample collection. However, it remains an underused strategy in translational research. Via an extensive questionnaire, we collected information on the study design, enrolment strategy, study conduct, sample and data management, and challenges and opportunities of research autopsy programmes in oncology worldwide. Fourteen programmes participated in this study. Eight programmes operated 24 h/7 days, resulting in a lower median postmortem interval (time between death and start of the autopsy, 4 h) compared with

SUBMITTER: Geukens T 

PROVIDER: S-EPMC11497336 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature