Association of long-term exposure to ozone with cardiovascular mortality and its metabolic mediators: evidence from a nationwide, population-based, prospective cohort study.

ABSTRACT:

Background

Previous studies about chronic effects of ozone (O₃) on cardiovascular mortality are scarce and inconclusive. We aimed to investigate the association between cardiovascular mortality and a broad range of long-term O₃ exposure levels.

Methods

This analysis included 3,206,871 participants aged 35-75 years enrolled in the ChinaHEART study. Participants were recruited from the 31 provinces of the Chinese mainland between January 2015 and December 2020. The five-year average O₃ concentrations before baseline visits were calculated to represent long-term exposure.

Findings

Over a median follow-up period of 4.7 (interquartile range: 3.7-6.2) years, 35,553 (1.1%) participants died from cardiovascular diseases (CVD). Following multiv

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11497431 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature