Severe mpox in an immunocompromised patient complicated by deep tissue infection: A case report.

ABSTRACT:

Objectives

We report prolonged mpox (>14 weeks) in a patient with HIV complicated by deep tissue MPXV infection despite two courses of tecovirimat treatment.

Methods

MPXV-DNA levels in lesional swabs, blood and tissue were quantified by qPCR. Anti-MPXV antibodies were analyzed by IF and VNT. Infectivity was assessed by virus isolation. Sequencing was performed to assess for tecovirimat resistance mutations and quantitative results were obtained by digital SNP PCR (A288P).

Results

The patient's clinical condition improved significantly during both tecovirimat treatment courses (each 14 days), yet we observed persistent MPXV-DNA in lesions accompanied by viremia (mean 1.4 × 10⁴ copies/ml) for >14 weeks. A deep tissue infection driven by MPXV complicated the c

SUBMITTER: Pfefferle S 

PROVIDER: S-EPMC11497435 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature