Synergistic combinations of novel polymyxins and rifampicin with improved eradication of colistin-resistant <i>Pseudomonas aeruginosa</i> biofilms.

ABSTRACT:

Background

Increased prevalence of antimicrobial resistance coupled with a lack of new antibiotics against Gram-negative bacteria emphasize the imperative for novel therapeutic strategies. Colistin-resistant Pseudomonas aeruginosa constitutes a challenge, where conventional treatment options lack efficacy, in particular for biofilm-associated infections. Previously, synergy of colistin with other antibiotics was explored as an avenue for the treatment of colistin-resistant infections, and recently we reported our efforts towards colistin analogs capable of combating planktonic colistin-resistant strains.

Aims

The aim of the present study was to investigate whether analogs of polymyxin B with improved potency in wild-type and moderate resistant Gram-negative pathogens

SUBMITTER: Jorgensen JS 

PROVIDER: S-EPMC11497480 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature