New Anti-Angiogenic Therapy for Glioblastoma With the Anti-Depressant Sertraline.

ABSTRACT:

Background and aims

Anti-angiogenic therapies prolong patient survival in some malignancies but not glioblastoma. We focused on the relationship between the differentiation of glioma stem like cells (GSCs) into tumor derived endothelial cells (TDECs) and, anti-angiogenic therapy resistance. Especially we aimed to elucidate the mechanisms of drug resistance of TDECs to anti-angiogenic inhibitors and identify novel anti-angiogenic drugs with clinical applications.

Results

The mouse GSCs, 005, were differentiated into TDECs under hypoxic conditions, and TDECs had endothelial cell characteristics independent of the vascular endothelial growth factor (VEGF) pathway. In vivo, inhibition of the VEGF pathway had no anti-tumor effect and increased the percentage of TDECs in the 005 m

SUBMITTER: Tsuboi N 

PROVIDER: S-EPMC11497491 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature