A biopsy-based Immunoscore in patients with treatment-naive resectable gastric cancer.

ABSTRACT:

Background

The prognostic significance of T-cell densities in gastric cancer (GC) was previously demonstrated in surgical resection specimens. For prognosis or response prediction, it is preferable to identify biomarkers in pre-treatment biopsies; yet, its representativeness of the tumor immune microenvironment is unclear.

Objectives

This study aimed to evaluate the concordance and prognostic value of T-cell densities in paired biopsies and resections.

Methods

Paired diagnostic biopsies and surgical resections were available for 131 patients with resectable GC who were treated with surgery alone in the D1/D2 trial. T-cell markers such as CD3, CD45RO, CD8, FOXP3, and Granzyme B were assessed by immunohistochemistry and digitally quantified. Tumors were categorized into

SUBMITTER: Soeratram TTD 

PROVIDER: S-EPMC11497501 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature