Associations of cerebral amyloid beta and tau with cognition from midlife.

ABSTRACT:

Introduction

Understanding early neuropathological changes and their associations with cognition may aid dementia prevention. This study investigated associations of cerebral amyloid and tau positron emission tomography (PET) retention with cognition in a predominately middle-aged community-based cohort and examined factors that may modify these relationships.

Methods

¹¹C-Pittsburgh compound B amyloid and ¹⁸F-flortaucipir tau PET imaging were performed. Associations of amyloid and tau PET with cognition were evaluated using linear regression. Interactions with age, apolipoprotein E (APOE) ε4 status, and education were examined.

Results

Amyloid and tau PET were not associated with cognition in the overall sample (N = 423; mean: 57 ± 10 years; 50%

SUBMITTER: Gonzales MM 

PROVIDER: S-EPMC11497641 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature