Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a devastating neurological disease with complex genetic etiology. Yet most known loci have only identified from the late-onset type AD in populations of European ancestry.

Methods

We performed a two-stage genome-wide association study (GWAS) of AD totaling 6878 Chinese and 63,926 European individuals.

Results

In addition to the apolipoprotein E (APOE) locus, our GWAS of two independent Chinese samples uncovered three novel AD susceptibility loci (KIAA2013, SLC52A3, and TCN2) and a novel ancestry-specific variant within EGFR (rs1815157). More replicated variants were observed in the Chinese (31%) than in the European samples (15%). In combining genome-wide associations and functional annotations, EGFR and TCN2 were prioritized a

SUBMITTER: Ge YJ 

PROVIDER: S-EPMC11497642 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature