Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer's disease.

ABSTRACT:

Introduction

We investigate the role of osteopontin (OPN) in participants with Pre-symptomatic Alzheimer's disease (AD), mild cognitive impairment (MCI), and in AD brains.

Methods

Cerebrospinal fluid (CSF) OPN, AD, and synaptic biomarker levels were measured in 109 cognitively unimpaired (CU), parental-history positive Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) participants, and in 167 CU and 399 participants with MCI from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. OPN levels were examined as a function of amyloid beta (Aβ) and tau positivity. Survival analyses investigated the link between OPN and rate of conversion to AD.

Results

In PREVENT-AD, CSF OPN was positively correlated with synapti

SUBMITTER: Quesnel MJ 

PROVIDER: S-EPMC11497655 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature