Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer's disease continuum.

ABSTRACT:

Introduction

Despite parallel research indicating amyloid-β accumulation, alterations in cortical neurophysiological signaling, and multi-system neurotransmitter disruptions in Alzheimer's disease (AD), the relationships between these phenomena remains unclear.

Methods

Using magnetoencephalography, positron emission tomography, and an atlas of 19 neurotransmitters, we studied the alignment between neurophysiological alterations, amyloid-β deposition, and the neurochemical gradients of the cortex.

Results

In patients with mild cognitive impairment and AD, changes in cortical rhythms were topographically aligned with cholinergic, serotonergic, and dopaminergic systems. These alignments correlated with the severity of clinical impairments. Additionally, cortical amyloid-

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC11497661 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature