Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.

ABSTRACT:

Introduction

We investigated the associations of leptin markers with cognitive function and magnetic resonance imaging (MRI) measures of brain atrophy and vascular injury in healthy middle-aged adults.

Methods

We included 2262 cognitively healthy participants from the Framingham Heart Study with neuropsychological evaluation; of these, 2028 also had available brain MRI. Concentrations of leptin, soluble leptin receptor (sOB-R), and their ratio (free leptin index [FLI]), indicating leptin bioavailability, were measured using enzyme-linked immunosorbent assays. Cognitive and MRI measures were derived using standardized protocols.

Results

Higher sOB-R was associated with lower fractional anisotropy (FA, β = -0.114 ± 0.02, p < 0.001), and higher free water (FW, β = 0.091 

SUBMITTER: Charisis S 

PROVIDER: S-EPMC11497668 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature