The MIND diet, brain transcriptomic alterations, and dementia.

ABSTRACT:

Introduction

Dietary patterns are associated with dementia risk, but the underlying molecular mechanisms are largely unknown.

Methods

We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants in the Religious Orders Study and Memory and Aging Project. We identified a transcriptomic profile correlated with the MIND diet (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay) among 482 individuals who completed ante mortem food frequency questionnaires; and examined its associations with cognitive health in the remaining 722 participants.

Results

We identified a transcriptomic profile, consisting of 50 genes, correlated with the MIND diet score (p = 0.001). Each

SUBMITTER: Li J 

PROVIDER: S-EPMC11497672 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature