Sustained frailty remission and dementia risk in older adults: A longitudinal study.

ABSTRACT:

Introduction

Physical frailty is reversible, but little is known about the sustainability of frailty remission and its impact on dementia.

Methods

Data were derived from the National Health and Aging Trends Study (NHATS) (2011 to 2021). Physical frailty was assessed using the Fried frailty phenotype, and frailty transition patterns across three waves were defined. The relationship of sustained frailty remission with incident dementia was examined using Cox proportional regression, stratified by age and gender.

Results

Among 1931 participants, 348 (18.0%) were capable of sustained frailty remission. During the 8-year follow-up, 279 participants developed dementia. In a fully adjusted model, sustained remission was associated with a lower risk of dementia (hazard ratio

SUBMITTER: Wang S 

PROVIDER: S-EPMC11497677 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature