Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [¹¹C]MPC-6827 PET imaging in rodent models of Alzheimer's-related pathology.

ABSTRACT:

Introduction

Microtubule (MT) stability is crucial for proper neuronal function. Understanding MT dysregulation is critical for connecting amyloid beta (Aβ) and tau-based degenerative events and early changes in presymptomatic Alzheimer's disease (AD). Herein we present positron emission tomography (PET) imaging properties of our MT-PET radiotracer, [¹¹C]MPC-6827, in multiple established AD mouse models.

Methods

Longitudinal PET, biodistribution, autoradiography, immunohistochemistry, and behavioral studies were conducted at multiple time points in APPswe/PSEN1dE9 (APP/PS1), P301S-PS19 (P301S), 5xFAD, and age-matched control mice.

Results

Longitudinal [¹¹C]MPC-6827 brain imaging showed significant increases in APP/PS1, P301S, and 5xFAD mice compa

SUBMITTER: Damuka N 

PROVIDER: S-EPMC11497705 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature