Association of cortical morphology, white matter hyperintensity, and glymphatic function in frontotemporal dementia variants.

ABSTRACT:

Introduction

Frontotemporal dementia (FTD) can be phenotypically divided into behavioral variant FTD (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA). However, the neural underpinnings of this phenotypic heterogeneity remain elusive.

Methods

Cortical morphology, white matter hyperintensities (WMH), diffusion tensor image analysis along the perivascular space (DTI-ALPS), and their interrelationships were assessed in subtypes of FTD. Neuroimaging-transcriptional analyses on the regional cortical morphological deviances among subtypes were also performed.

Results

Changes in cortical thickness, surface area, gyrification, WMH, and DTI-ALPS were subtype-specific in FTD. The three morphologic indices are related to whole-brai

SUBMITTER: Xiao D 

PROVIDER: S-EPMC11497707 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature