CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease.

ABSTRACT:

Introduction

We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF), and plasma GFAP are associated with cognitive change in cognitively unimpaired (CU) individuals at risk of Alzheimer's disease (AD).

Methods

A total of 353 CU (mean age 60.9 years) participants were included (mean follow-up time 3.28 years). Linear regression models with cognition as outcome were used. We also tested whether amyloid beta (Aβ) status modified these associations.

Results

Higher baseline CSF sTREM2 was associated with a positive global cognition (Preclinical Alzheimer's Cognitive Composite) rate of change, and better memory an

SUBMITTER: Warmenhoven N 

PROVIDER: S-EPMC11497712 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature