Prospects and challenges in using neuronal extracellular vesicles in biomarker research.

ABSTRACT: Extracellular vesicles (EVs) hold promise as a source of disease biomarkers. The diverse molecular cargo of EVs can potentially indicate the status of their tissue of origin, even against the complex background of whole plasma. The main tools currently available for assessing biomarkers of brain health include brain imaging and analysis of the cerebrospinal fluid of patients. Given the costs and difficulties associated with these methods, isolation of EVs of neuronal origin (NEVs) from the blood is an attractive approach to identify brain-specific biomarkers. This perspective describes current key challenges in EV- and NEV-based biomarker research. These include the relative low abundance of EVs, the lack of validated isolation methods, and the difficult search for an adequate target for i

SUBMITTER: Rocha DAS 

PROVIDER: S-EPMC11497720 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature