Impaired glymphatic function as a biomarker for subjective cognitive decline: An exploratory dual cohort study.

ABSTRACT:

Background

Subjective cognitive decline (SCD) has been recognized as a potential risk stage for progression to Alzheimer's disease (AD), while glymphatic dysfunction is considered an important characteristic of AD. We hypothesize that glymphatic dysfunction occurs during the SCD stage, aiming to discover potential biomarkers for SCD.

Methods

Participants from two independent studies, Sino Longitudinal Study on Cognitive Decline (SILCODE, n = 654) and the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 650), representing different ethnicities and disease stages, were included to assess glymphatic function using diffusion tensor image analysis along the perivascular space (DTI-ALPS).

Results

Abnormal glymphatic function occurs during the SCD stage, with the ALPS

SUBMITTER: Li Y 

PROVIDER: S-EPMC11497721 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature