Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

ABSTRACT:

Introduction

The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.

Methods

In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on dise

SUBMITTER: Kloske CM 

PROVIDER: S-EPMC11497726 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature