A genome-wide association meta-analysis of all-cause and vascular dementia.

ABSTRACT:

Introduction

Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD.

Methods

We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors.

Results

For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance

SUBMITTER: Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium 

PROVIDER: S-EPMC11497727 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature