Predicting continuous amyloid PET values with CSF tau phosphorylation occupancies.

ABSTRACT:

Introduction

Cerebrospinal fluid (CSF) tau phosphorylation at multiple sites is associated with cortical amyloid and other pathologic changes in Alzheimer's disease. These relationships can be non-linear. We used an artificial neural network to assess the ability of 10 different CSF tau phosphorylation sites to predict continuous amyloid positron emission tomography (PET) values.

Methods

CSF tau phosphorylation occupancies at 10 sites (including pT181/T181, pT217/T217, pT231/T231 and pT205/T205) were measured by mass spectrometry in 346 individuals (57 cognitively impaired, 289 cognitively unimpaired). We generated synthetic amyloid PET scans using biomarkers and evaluated their performance.

Results

Concentration of CSF pT217/T217 had low predictive error (average err

SUBMITTER: Wisch JK 

PROVIDER: S-EPMC11497729 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature