Design and validation of the ADNI MR protocol.

ABSTRACT: Phase four of the Alzheimer's Disease Neuroimaging Initiative (ADNI4) magnetic resonance imaging (MRI) protocols aim to maintain longitudinal consistency across two decades of data acquisition, while adopting new technologies. Here we describe and justify the study's design and targeted biomarkers. The ADNI4 MRI protocol includes nine MRI sequences. Some sequences require the latest hardware and software system upgrades and are continuously rolled out as they become available at each site. The main sequence additions/changes in ADNI4 are: (1) compressed sensing (CS) T1-weighting, (2) pseudo-continuous arterial spin labeling (ASL) on all three vendors (GE, Siemens, Philips), (3) multiple-post-labeling-delay ASL, (4) 1 mm³ isotropic 3D fluid-attenuated inversion recovery, and (5)

SUBMITTER: Arani A 

PROVIDER: S-EPMC11497751 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature